Pharmacophore Models of Paclitaxel- and Epothilone-Based Microtubule Stabilizing Agents
نویسندگان
چکیده
Department of Immunology, Beckman Research Institute of the City of Hope, CA 91010, USA Division of Applied Life Science (BK21 Program), Systems and Synthetic Agrobiotech Center (SSAC), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), Jinju 660-701, Korea. E-mail: [email protected] Department of Biology and Biochemistry, University of Houston, TX 77204-5001, USA. E-mail: [email protected] Received February 25, 2013, Accepted April 1, 2013
منابع مشابه
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)).
Epothilones A and B, natural products with minimal structural analogy to taxoids, have effects similar to those of paclitaxel (Taxol(R)) in cultured cells and on microtubule protein, but differ from paclitaxel in retaining activity in multidrug-resistant cells. We examined interactions of the epothilones with purified tubulin and additional cell lines, including a paclitaxel-resistant ovarian c...
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تاریخ انتشار 2013